Our ability to discover effective drug combinations is limited, in part by insufficient understanding of how the transcriptional response of two monotherapies results in that of their combination.We analyzed matched time course RNAseq profiling of cells treated with single drugs and their combinations and found that the transcriptional signature of

Nucleic acid sensor elements are proving increasingly useful in biotechnology and biomedical applications.A number of ligand-sensing, conformational-switching ribozymes (also known as allosteric ribozymes or aptazymes) have been generated by some combination of directed evolution or rational design.Such sensor elements typically fuse a molecular re

Adhesion robots have broad application prospects in the field of spacecraft inspection, repair, and maintenance, but the stable adhesion and climbing on the flexible surface covering the spacecraft has not been achieved.The flexible surface is easily deformed when subjected to external force, which makes it difficult to ensure a sufficient contact

In problems of global hydroelastic ship response in severe seas including the whipping problem, we need to know the hydrodynamic forces acting on the ship hull during almost arbitrary ship motions.In terms of ship sections, some of them can enter water but others exit from water.Computations of nonlinear free surface flows, pressure distributions a

Background:.Informed consent is a fundamental pillar of patient rights and is an essential part of good clinical practice.In 2019, the International Confederation of Plastic Surgery Societies launched a survey to collect feedback on informed consent practices, with an aim to develop an international guideline for cosmetic surgery Methods:.A 15-ques